Dr. Shengtong Han, assistant professor of biostatistics at the Marquette University School of Dentistry, will present the mathematical and statistical sciences colloquium on Friday, April 24, at 1 p.m. in Cudahy Hall 401.
In this talk, Han will discuss a Bayesian method (mixture-model-based rare-variant analysis on genes (MIRAGE) to boost the power in the rare variant association test (RVAT). MIRAGE takes summary statistics as input, and it captures the heterogeneity of variant effects by treating all variants of a gene as a mixture of risk and non-risk variants and uses external information of variants to model the prior probabilities of being risk variants.
